Benzenepropanal → HCID 70454248, compound

HRID 1248823Notes

Reaction equation

HRID 1248823 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[S:13][N:12]=[C:11]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:20](=[O:29])[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:1]([O:5][C:6]([NH:8][C:9]1[S:13][N:12]=[C:11]([CH:14]([CH:20]([OH:29])[CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 7707BenzenepropanalHCID 20226075HCID 20226075, compound

Product 1

HCID 70454248HCID 70454248, compound

Procedure

1.0 g (3.5 mMol) of product from Example 28 were reacted with 1.4 ml (~10 mMol) of dihydrocinnamaldehyde for 5 days in the manner described in Example 29 and, after working up by aqueous extraction, the product was chromatographed on 25 g of silica gel using toluene/ethyl acetate (4:1) and separated into the erythro and threo forms.

Workup

  1. extractionafter working up by aqueous extraction
  2. customthe product was chromatographed on 25 g of silica gel
  3. customseparated into the erythro and threo forms

Sources & evidence

ORD record
ord-4225777514714ad5a4b50c7b0cca303b
Source dataset
uspto-grants-1986_12
Patent number
US04626535

Reaction notes

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