Hydrochloric Acid → HCID 70348886, compound

HRID 1248825Notes

Reaction equation

HRID 1248825 reaction equation
O[CH:2]1C[CH2:5][N:4](C2C=CC(O)=CC=2)[CH2:3]1.[C:14]([O-])(=O)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[ClH:23].[OH2:24]>>[OH:24][C:18]1[CH:19]=[CH:20][C:15]([C:14]2[CH2:5][NH:4][CH2:3][CH:2]=2)=[CH:16][CH:17]=1.[ClH:23]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86741139HCID 86741139, compound

Product 1

HCID 70348886HCID 70348886, compound

Procedure

3.0 g (0.01 mol) of 3-hydroxy-(4-hydroxyphenyl)pyrrolidine·benzoate are dissolved in 100 ml of water. The solution is then brought to pH 1 with concentrated hydrochloric acid. The benzoic acid precipitated is extracted with ether and the clear aqueous solution evaporated. The solid residue is recrystallized from ethanol. There is obtained 3-(4-hydroxyphenyl)-3-pyrroline·HCl in the form of light beige crystals, mp 222° C. (from ethanol).

Workup

  1. customThe benzoic acid precipitated
  2. extractionis extracted with ether
  3. customthe clear aqueous solution evaporated
  4. customThe solid residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-8a6793a433a0434dad1f49d5bb13f97a
Source dataset
uspto-grants-1986_12
Patent number
US04626546

Reaction notes

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