Triethylamine → HCID 13649702, compound

Participants

Reaction Steps

5 g (0.025 mole) of 4-amino-2,5-difluoro-6-trifluoromethylpyrimidine are dissolved in 150 ml of dioxane. 2.9 g (0.025 mole) of 3-isopropoxypropylamine and 2.5 g (0.025 mole) of triethylamine are added dropwise thereto and the reaction mixture is heated to the boil for five hours. It is cooled and stirred into ice water, and the resulting solid is filtered off, dried and recrystallised from white spirit. 4 g (54% of theory) of the desired pyrimidine, melting point 87° C., are obtained.

Provenance & Evidence