Triethylamine → HCID 13649702, compound

HRID 1248887Notes

Reaction equation

HRID 1248887 reaction equation
[NH2:1][C:2]1[C:7]([F:8])=[C:6]([C:9]([F:12])([F:11])[F:10])[N:5]=[C:4](F)[N:3]=1.[CH:14]([O:17][CH2:18][CH2:19][CH2:20][NH2:21])([CH3:16])[CH3:15].C(N(CC)CC)C>O1CCOCC1>[NH2:1][C:2]1[C:7]([F:8])=[C:6]([C:9]([F:12])([F:11])[F:10])[N:5]=[C:4]([NH:21][CH2:20][CH2:19][CH2:18][O:17][CH:14]([CH3:16])[CH3:15])[N:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 761943-IsopropoxypropylamineHCID 13026344HCID 13026344, compound

Product 1

HCID 13649702HCID 13649702, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5 g (0.025 mole) of 4-amino-2,5-difluoro-6-trifluoromethylpyrimidine are dissolved in 150 ml of dioxane. 2.9 g (0.025 mole) of 3-isopropoxypropylamine and 2.5 g (0.025 mole) of triethylamine are added dropwise thereto and the reaction mixture is heated to the boil for five hours. It is cooled and stirred into ice water, and the resulting solid is filtered off, dried and recrystallised from white spirit. 4 g (54% of theory) of the desired pyrimidine, melting point 87° C., are obtained.

Workup

  1. temperaturethe reaction mixture is heated to the boil for five hours
  2. temperatureIt is cooled
  3. filtrationthe resulting solid is filtered off
  4. customdried
  5. customrecrystallised from white spirit

Sources & evidence

ORD record
ord-13b10476769640c5a89da7e34bc82b15
Source dataset
uspto-grants-1986_12
Patent number
US04627872

Reaction notes

Loading…