Water → HCID 13565135, compound

Participants

Reaction Conditions

Reaction Steps

22.8 g (0.1 mole) of 3-chloro-4-pivaloylamino-phenol were dissolved in 150 ml of dimethylsulphoxide. 5.6 g (0.1 mole) of powdered potassium hydroxide were added in portions at room temperature, with stirring. The mixture was subsequently stirred at room temperature for 30 minutes and 14.25 g (0.1 mole) of 2-chloro-4,6-dimethyl-pyrimidine were then added in portions. The mixture was heated to 120° C. in the course of 1 hour and subsequently stirred at this temperature for a further 5 hours. The mixture was then cooled and poured into one liter of water. The crystals were filtered off with suction and dried in air. 25.5 g (76.5% of theory) of 2-(3-chloro-4-pivaloylamino-phenoxy)-4,6-dimethylpyrimidine were obtained.

Provenance & Evidence