Methyl iodide → 4-(3',5'-Difluorobenzyl)-3-methylthio-1,2,4-triazole

HRID 1248943Notes

Reaction equation

HRID 1248943 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[C:13]([F:15])[CH:14]=1)[CH2:5][N:6]1[CH:10]=[N:9][N:8]=[C:7]1[SH:11].[CH3:16]I.C[O-].[Na+]>CO>[F:15][C:13]1[CH:12]=[C:4]([CH:3]=[C:2]([F:1])[CH:14]=1)[CH2:5][N:6]1[CH:10]=[N:9][N:8]=[C:7]1[S:11][CH3:16]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 10942334Sodium MethoxideHCID 178505926HCID 178505926, compound

Product 1

HCID 202257254-(3',5'-Difluorobenzyl)-3-methylthio-1,2,4-triazole

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction of 4-(3',5'-difluorobenzyl)-1,2,4-triazole-3-thiol (prepared as in Example 3) with methyl iodide and sodium methoxide in methanol by known techniques yields 4-(3',5'-difluorobenzyl)-3-methylthio-1,2,4-triazole.

Sources & evidence

ORD record
ord-d3abad940751433185a098fa8dba367d
Source dataset
uspto-grants-1986_12
Patent number
US04628059

Reaction notes

Loading…