反应详情

A mixture of 9.5 g. of methyl 2-bromo-3-pyrazine carboxylate, 8.2 g. of aniline, 0.5 g. of p-toluene sulfonic acid and 100 ml. of water is stirred and refluxed for two hours. The reaction mixture is poured on ice, extracted with ethyl acetate, the organic extracts are dried and concentrated to yield an oil. The crude residue is eluted on a silica gel column with ethylacetate-hexane (1:2) yielding the product of this example as a yellow solid, m.p. 72°-75° C.

1. additionA mixture of 9.5 g
2. temperaturerefluxed for two hours
3. additionThe reaction mixture is poured on ice
4. extractionextracted with ethyl acetate
5. customthe organic extracts are dried
6. concentrationconcentrated
7. customto yield an oil
8. washThe crude residue is eluted on a silica gel column with ethylacetate-hexane (1:2)
9. customyielding the product of this example as a yellow solid, m.p. 72°-75° C.