Ethanol → HCID 13374891, compound

HRID 1249000Notes

Reaction equation

HRID 1249000 reaction equation
[C:1]1([C:7]2[S:8][C:9]3[C:14]([C:15](=[O:17])[CH:16]=2)=[CH:13][CH:12]=[CH:11][C:10]=3C=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20]([O:26][CH2:27][CH2:28][CH2:29][CH3:30])(=[O:25])[CH2:21][C:22]([CH3:24])=O.[NH2:31]/[C:32](/[CH3:36])=[CH:33]\[C:34]#[N:35].[CH2:37](O)C>>[C:34]([C:33]1[CH:37]([C:10]2[CH:11]=[CH:12][CH:13]=[C:14]3[C:9]=2[S:8][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:16][C:15]3=[O:17])[C:21]([C:20]([O:26][CH2:27][CH2:28][CH2:29][CH3:30])=[O:25])=[C:22]([CH3:24])[NH:31][C:32]=1[CH3:36])#[N:35]

Participants

5

Reactant 4

HCID 702EthanolHCID 11576Butyl acetoacetateHCID 5325263(2Z)-3-Amino-2-butenenitrileHCID 133748414-Oxo-2-phenyl-4H-1-benzothiopyran-8-carbaldehyde

Product 1

HCID 13374891HCID 13374891, compound

Procedure

10 mmol each of 2-phenyl-4-oxo-4H-thiochromen-8-aldehyde, butyl acetoacetate and 3-aminocrotononitrile were boiled under reflux in 30 ml of ethanol overnight, the mixture was concentrated and the residue was crystallized with ethyl acetate.

Workup

  1. concentrationthe mixture was concentrated
  2. customthe residue was crystallized with ethyl acetate

Sources & evidence

ORD record
ord-11bdf0fae6eb4be3ab4efae1ea00a56a
Source dataset
uspto-grants-1986_12
Patent number
US04628107

Reaction notes

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