Pyridine → HCID 131714991, compound

HRID 1249019Notes

Reaction equation

HRID 1249019 reaction equation
[NH2:1][C@H:2]([C:8]([N:10]1[CH2:34][CH2:33][CH2:32][C@H:11]1[C:12]([NH:14][C@H:15]([C:21]([NH:23][C@H:24]([C:29]([OH:31])=[O:30])[CH2:25][C:26](=[O:28])[NH2:27])=[O:22])[CH2:16][CH2:17][C:18](=[O:20])[OH:19])=[O:13])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].[C:35](Cl)(=[O:37])[CH3:36].N1C=CC=CC=1>O1CCCC1>[NH:1]([C:35]([CH3:36])=[O:37])[C@H:2]([C:8]([N:10]1[CH2:34][CH2:33][CH2:32][C@H:11]1[C:12]([NH:14][C@H:15]([C:21]([NH:23][C@H:24]([C:29]([OH:31])=[O:30])[CH2:25][C:26](=[O:28])[NH2:27])=[O:22])[CH2:16][CH2:17][C:18](=[O:19])[OH:20])=[O:13])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 131714992HCID 131714992, compound

Product 1

HCID 131714991HCID 131714991, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 500 mg of Gln-Pro-Glu-Asn, 0.7 ml of acetyl choride, 0.5 ml of pyridine and 10 ml of tetrahydrofuran is kept at 20° for 12 hours. The mixture is evaporated, the residue is purified by means of TLC to yield Ac-Gln-Pro-Glu-Asn.

Workup

  1. customThe mixture is evaporated
  2. customthe residue is purified by means of TLC

Sources & evidence

ORD record
ord-2f8f9efcb8b74626846721aa14eda267
Source dataset
uspto-grants-1986_12
Patent number
US04628045

Reaction notes

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