反应详情

To (S)-2-methanesulfonyloxy-1,1-diphenyl-1-propanol (153 mg, 0.5 mmol) present in 5 ml of CH2Cl2 in Referential example 3 was added a hexane solution of triethylaluminum (0.6 mmol, 0.7 ml) slowly at -78° C. The color of the solution changed to yellow. After stirred further for 30 minutes, the reaction was stopped with three drops of phosphate buffer solution having a pH value of 7. The suspension obtained was diluted with ethyl acetate, dried over anhydrous Na2SO4, filtered and concentrated. Oily residue was subjected to the chromatography treatment with Florisil column to obtain 1,2-diphenyl-1-propanone (100 mg, 96%).

1. customThe suspension obtained
2. dry with materialdried over anhydrous Na2SO4
3. filtrationfiltered
4. concentrationconcentrated