Carbon Disulfide → HCID 13561923, compound

HRID 1249029Notes

Reaction equation

HRID 1249029 reaction equation
[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH2:4][CH:3]([C:14]([OH:16])=[O:15])[NH:2]1.[OH-].[K+].[CH:19](I)([CH3:21])[CH3:20].[C:23](=[S:25])=[S:24]>>[CH:19]([S:25][C:23]([N:2]1[CH:3]([C:14]([OH:16])=[O:15])[CH2:4][C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[NH:12][C:13]=2[CH2:1]1)=[S:24])([CH3:21])[CH3:20]

Participants

5

Reactant 4

HCID 6348Carbon DisulfideHCID 6362Isopropyl iodideHCID 14797Potassium HydroxideHCID 982851,2,3,4-Tetrahydro-Beta-Carboline-3-Carboxylic Acid

Product 1

HCID 13561923HCID 13561923, compound

Procedure

In the same manner as described in Example 6, (3RS)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (3.24 g), KOH (96%, 1.75 g), carbon disulfide (0.91 ml) and isopropyl iodide (1.8 ml) are reacted and treated. The product is crystallized from chloroform to give the title compound (1.59 g) as colorless needles, m.p. 188°-190° C.

Workup

  1. customare reacted
  2. additiontreated
  3. customThe product is crystallized from chloroform

Sources & evidence

ORD record
ord-358e110fd96046929743a84d941a7164
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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