反应详情

In the same manner as described in Example 6, (3RS)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (3.24 g), KOH (1.75 g), 50% ethanol (70 ml), carbon disulfide (0.91 ml) and methylthiomethyl chloride (1.74 g) are reacted and treated. The product thus obtained is purified by silica gel column chromatography (solvent, chloroform:methanol:acetic acid=97:2:1) to give the title compound (2.61 g) as a pale yellow powder.

1. customare reacted
2. additiontreated
3. customThe product thus obtained
4. customis purified by silica gel column chromatography (solvent, chloroform:methanol:acetic acid=97:2:1)