Ethanol → (3RS)-2-[(Methylthiomethylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid

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Reaction Steps

In the same manner as described in Example 6, (3RS)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (3.24 g), KOH (1.75 g), 50% ethanol (70 ml), carbon disulfide (0.91 ml) and methylthiomethyl chloride (1.74 g) are reacted and treated. The product thus obtained is purified by silica gel column chromatography (solvent, chloroform:methanol:acetic acid=97:2:1) to give the title compound (2.61 g) as a pale yellow powder.

Provenance & Evidence