HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Disulfide → (3S)-2-[(2-Thenylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-(Chloromethyl)thiophene | HCID 69830 | — |
| Reactant | (3S)-1H,2H,3H,4H,9H-pyrido(3,4-b)indole-3-carboxylic acid | HCID 449440 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (3S)-2-[(2-Thenylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid | HCID 13561951 | — |
Reaction Steps
In the same manner as descsribed in Example 32, (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (4.33 g), KOH (2.33 g), carbon disulfide (1.22 ml), 50% ethanol (80 ml) and 2-thenyl chloride (3.1 g) are reacted and treated to give the title compound (3.15 g) as pale yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04628057 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-f348eaa2c3184b9e91e3045572b277be |
| Source note | uspto-grants-1986_12 |