Carbon Disulfide → HCID 13561977, compound

HRID 1249065Notes

Reaction equation

HRID 1249065 reaction equation
[CH2:1]([N:8]1[C:20]2[CH2:19][NH:18][C@@H:17]([C:21]([OH:23])=[O:22])[CH2:16][C:15]=2[C:14]2[C:9]1=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].[C:26](=[S:28])=[S:27].[C:29]1([CH2:34]Cl)[S:33][CH:32]=[CH:31][CH:30]=1>CS(C)=O>[CH2:1]([N:8]1[C:20]2[CH2:19][N:18]([C:26]([S:28][CH2:34][C:29]3[S:33][CH:32]=[CH:31][CH:30]=3)=[S:27])[C@@H:17]([C:21]([OH:23])=[O:22])[CH2:16][C:15]=2[C:14]2[C:9]1=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 6348Carbon DisulfideHCID 14798Sodium HydroxideHCID 698302-(Chloromethyl)thiopheneHCID 13562005HCID 13562005, compound

Product 1

HCID 13561977HCID 13561977, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In the same manner as described in Example 51, (3R)-9-benzyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (1.225 g), 10N NaOH (0.8 ml), carbon disulfide (0.24 ml), dimethylsulfoxide (30 ml) and 2-thenyl chloride (0.66 g) are reacted and treated to give the title compound (0.635 g) as pale yellow powder.

Workup

  1. customare reacted
  2. additiontreated

Sources & evidence

ORD record
ord-35783251e50f4134883863c3e9c97073
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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