HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Disulfide → Methyl (3RS)-9-methyl-2-[(2-thenylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(Chloromethyl)thiophene | HCID 69830 | — |
| Reactant | methyl (3RS)-9-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate | HCID 12789147 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl (3RS)-9-methyl-2-[(2-thenylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate | HCID 13561991 | 57.6% |
Reaction Steps
In the same manner as described in Example 53, methyl (3RS)-9-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (421 mg), triethylamine (365 mg), carbon disulfide (137 mg), methanol (20 ml) and 2-thenyl chloride (238 mg) are reacted and treated. The product is recrystallized from methanol to give the title compound (360 mg, 57.6%) as colorless prisms, m.p. 139°-140° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04628057 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-0a672be6ae5b486d8968a04da98745d0 |
| Source note | uspto-grants-1986_12 |