Methyl iodide → HCID 86741155, compound

HRID 1249085Notes

Reaction equation

HRID 1249085 reaction equation
[CH2:1]([C@H:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][C@H:6]([C:17]([OH:19])=[O:18])[NH:5]1)[CH2:2][CH3:3].C(N(CC)CC)C.[C:27](=[S:29])=[S:28].[CH3:30]I>C(O)C.CO>[CH2:1]([C@H:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][C@H:6]([C:17]([OH:19])=[O:18])[N:5]1[C:27]([S:29][CH3:30])=[S:28])[CH2:2][CH3:3]

Participants

7

Reactant 4

HCID 6328Methyl iodideHCID 6348Carbon DisulfideHCID 8471TriethylamineHCID 762192HCID 762192, compound

Product 1

HCID 86741155HCID 86741155, compoundYield 38.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

In the same manner as described in Example 73, (1RS,3SR)-trans-1-n-propyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (0.9 g), triethylamine (0.4 g), carbon disulfide (0.3 g), methyl iodide (0.56 g) and 80% methanol (14 ml) are reacted and treated. The product is treated with aqueous ethanol to give the title compound (0.47 g) as pale yellow powder.

Workup

  1. customare reacted
  2. additiontreated

Sources & evidence

ORD record
ord-18a3257665384a71a13b15fdb6f3c7dc
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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