Sodium Hydroxide → HCID 1769747, compound

HRID 1249091Notes

Reaction equation

HRID 1249091 reaction equation
[CH2:1]([C@H:5]1[C:17]2[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]=2[CH2:8][C@@H:7]([C:18]([O:20]C)=[O:19])[NH:6]1)[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>CO>[CH2:1]([C@H:5]1[C:17]2[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]=2[CH2:8][C@@H:7]([C:18]([OH:20])=[O:19])[NH:6]1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 40535464HCID 40535464, compound

Product 1

HCID 1769747HCID 1769747, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the same manner as described in Reference Example 2-(1) using methyl (1RS,3RS)-cis-1-butyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (1.43 g), 1N NaOH (5.5 ml) and methanol (30 ml), there is obtained the title compound (1.06 g, 78%) as colorless needles, m.p. 215°-216° C. (recrystallized from methanol).

Workup

  1. customthere is obtained
  2. customthe title compound (1.06 g, 78%) as colorless needles, m.p. 215°-216° C. (recrystallized from methanol)

Sources & evidence

ORD record
ord-6f66690300c04259ad46cd2f1b19b95b
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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