Sodium Hydroxide → HCID 6997614, compound

HRID 1249094Notes

Reaction equation

HRID 1249094 reaction equation
[OH:1][CH2:2][C@H:3]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH2:6][C@H:5]([C:16]([O:18]C)=[O:17])[NH:4]1.[OH-].[Na+]>CO>[OH:1][CH2:2][C@H:3]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH2:6][C@H:5]([C:16]([OH:18])=[O:17])[NH:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12789156HCID 12789156, compound

Product 1

HCID 6997614HCID 6997614, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the same manner as described in Reference Example 2-(1) using methyl (1RS,3SR)-trans-1-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (2.60 g), 10N NaOH (1.2 ml) and methanol (50 ml), there is obtained the title compound (1.60 g, 65%), m.p. 231°-233°C.

Sources & evidence

ORD record
ord-5970c668d7054bcdbc4fd67b21347461
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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