Hydrogen Bromide → HCID 178419865, compound

HRID 1249104Notes

Reaction equation

HRID 1249104 reaction equation
C(OC([N:11]1[CH:23]([C:24]2[NH:28][N:27]=[N:26][N:25]=2)[CH2:22][C:21]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][C:13]=2[CH2:12]1)=O)C1C=CC=CC=1.Br.CCOCC>C(O)(=O)C>[NH:28]1[C:24]([CH:23]2[CH2:22][C:21]3[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[NH:14][C:13]=3[CH2:12][NH:11]2)=[N:25][N:26]=[N:27]1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 178525095HCID 178525095, compound

Product 1

HCID 178419865HCID 178419865, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

(3RS)-2-Benzyloxycarbonyl-3-(1H-tetrazol-5-yl)-1,2,3,4-tetrahydro-β-carboline (0.3 g) is dissolved in acetic acid (1 ml) and thereto is added dropwise a 25% solution of HBr in acetic acid (2 ml). The mixture is stirred at room temperature for 20 minutes, and thereto is added ether. The precipitates are collected by filtration, washed with ether and dried to give the title compound (0.257 g, quantitatively) as pale yellow powder.

Workup

  1. filtrationThe precipitates are collected by filtration
  2. washwashed with ether
  3. customdried

Sources & evidence

ORD record
ord-f7a18b5a605743848048fd6678ac96d5
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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