反应详情

In 100 ml of methyl ethyl ketone, 2.3 g of the intermediate of Preparation 1 of 2-(4-hydroxyphenoxy)quinoline, 1.8 g of N,N-dimethyl-α-bromopropionic acid amide and 1.4 g of potassium carbonate were added and the mixture was refluxed for 5 hours. After the reaction, the precipitated crystal was separated by a filtration and the solvent was distilled off and the product was dried under a reduced pressure. The resulting crude crystal was recrystallized from a solvent of methanol-water to obtain 3.6 g (yield 88%) of white crystal of the object compound.

1. additionwere added
2. temperaturethe mixture was refluxed for 5 hours
3. customAfter the reaction
4. customthe precipitated crystal was separated by a filtration
5. distillationthe solvent was distilled off
6. customthe product was dried under a reduced pressure
7. customThe resulting crude crystal was recrystallized from a solvent of methanol-water