反应详情

To 3.2 g of N-methyl methanesulfonamide in 50 ml of dry dimethylformamide is added 1.47 g of potassium methoxide. The mixture is stirred for 15 minutes. 2.8 g of 2-Fluoronitrobenzene is added and the mixture is heated to reflux for two hours. The dimethylformamide is removed on a rotary evaporator. The concentrated reaction mixture is poured into water. The crude product is extracted with CH2Cl2. The crude extracts are dried with MgSO4, filtered and concentrated on a rotary evaporator. The crude product is purified by recrystallization from butyl chloride-ethyl acetate. 3.4 g of product with m.p. 144°-145° C. is obtained.

1. temperaturethe mixture is heated
2. temperatureto reflux for two hours
3. customThe dimethylformamide is removed on a rotary evaporator
4. customThe concentrated reaction mixture
5. extractionThe crude product is extracted with CH2Cl2
6. dry with materialThe crude extracts are dried with MgSO4
7. filtrationfiltered
8. concentrationconcentrated on a rotary evaporator
9. customThe crude product is purified by recrystallization from butyl chloride-ethyl acetate