Formaldehyde → HCID 20225020, compound

HRID 1249173Notes

Reaction equation

HRID 1249173 reaction equation
O.[ClH:2].Cl.[O:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][NH:12][CH2:13][C:14]2([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=3)[CH2:17][CH2:16][CH2:15]2)[CH2:6][CH2:5]1.[CH2:26]=O.[OH-].[Na+]>C(O)=O>[ClH:24].[ClH:2].[CH3:26][N:12]([CH2:13][C:14]1([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=2)[CH2:15][CH2:16][CH2:17]1)[CH2:11][CH2:10][N:7]1[CH2:6][CH2:5][O:4][CH2:9][CH2:8]1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 20225053HCID 20225053, compound

Product 1

HCID 20225020HCID 20225020, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The product of Example 74 in the form of its free base (0.55 g) 98% formic acid (4 ml) and 37-40% aqueous formaldehyde were heated at 70°-80° C. for four hours. The reaction mixture was cooled and basified with aqueous sodium hydroxide solution. The mixture was then extracted with ether and the ether extract washed and dried. Hydrogen chloride gas was passed through the extract to give N-methyl-N-(2-morpholinoethyl)-[1-(3,4-dichlorophenyl)cyclobutyl]methylamine dihydrochloride (m.p. 233°-235° C.).

Workup

  1. temperatureThe reaction mixture was cooled
  2. extractionThe mixture was then extracted with ether
  3. extractionthe ether extract
  4. washwashed
  5. customdried
  6. extractionextract

Sources & evidence

ORD record
ord-f5bda073b2004812a52173c8b09852ba
Source dataset
uspto-grants-1986_12
Patent number
US04629727

Reaction notes

Loading…