Formaldehyde → HCID 20225020, compound

Participants

Reaction Steps

The product of Example 74 in the form of its free base (0.55 g) 98% formic acid (4 ml) and 37-40% aqueous formaldehyde were heated at 70°-80° C. for four hours. The reaction mixture was cooled and basified with aqueous sodium hydroxide solution. The mixture was then extracted with ether and the ether extract washed and dried. Hydrogen chloride gas was passed through the extract to give N-methyl-N-(2-morpholinoethyl)-[1-(3,4-dichlorophenyl)cyclobutyl]methylamine dihydrochloride (m.p. 233°-235° C.).

Provenance & Evidence