Chloroacetonitrile → 2-[Ethyl(heptyl)amino]acetonitrile

HRID 1249187노트

반응식

HRID 1249187 반응식
[CH2:1]([NH:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:2].Cl[CH2:12][C:13]#[N:14].C(=O)([O-])[O-].[Na+].[Na+]>C1(C)C=CC=CC=1>[CH2:1]([N:3]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH2:12][C:13]#[N:14])[CH3:2]

참가 물질

5

반응물 3

HCID 7856ChloroacetonitrileHCID 10340Sodium CarbonateHCID 480381-Heptanamine, N-ethyl-

생성물 1

HCID 202253242-[Ethyl(heptyl)amino]acetonitrile

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
125 °C

실험 절차

Combine 7.95 g (0.055 moles) ethyl(heptyl)amine, 3.5 ml (0.055 moles) chloroacetonitrile, 5.8 g (0.055 moles) sodium carbonate and 25 ml toluene in a sealed pressure tube. Heat to 125° C. for 18 hrs. Follow the progress of the reaction by thin layer chromatography on silica gel (CH3CN+MeOH+NH4OH, 85+10+5). At the completion of the reaction, filter the reaction mixture and evaporate the solvents to provide the title compound.

후처리

  1. customthe progress of the reaction by thin layer chromatography on silica gel (CH3CN+MeOH+NH4OH, 85+10+5)
  2. customAt the completion of the reaction
  3. filtrationfilter the reaction mixture
  4. customevaporate the solvents

출처 및 근거

ORD 기록
ord-cd3f4c535923482a92d0056b5625a353
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04629739

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