N-Ethylethylenediamine → N-[2-(Ethylamino)ethyl]-4-[(methylsulfonyl)amino]benzamide hydrochloride

HRID 1249195ノート

反応式

HRID 1249195 の反応式
[CH2:1]([NH:3][CH2:4][CH2:5][NH2:6])[CH3:2].[CH3:7][S:8]([NH:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([Cl:18])=[O:17])=[CH:14][CH:13]=1)(=[O:10])=[O:9]>O1CCCC1>[ClH:18].[CH2:1]([NH:3][CH2:4][CH2:5][NH:6][C:16](=[O:17])[C:15]1[CH:19]=[CH:20][C:12]([NH:11][S:8]([CH3:7])(=[O:10])=[O:9])=[CH:13][CH:14]=1)[CH3:2]

参加物

4

反応物 2

HCID 66071N-EthylethylenediamineHCID 117911194-[(Methylsulfonyl)amino]benzoyl chloride

生成物 1

HCID 20225356N-[2-(Ethylamino)ethyl]-4-[(methylsulfonyl)amino]benzamide hydrochloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 4.45 g (50.5 mmoles) of N-ethylethylenediamine in 50 ml of tetrahydrofuran cooled in an ice/ethanol bath under a nitrogen atmosphere add dropwise a solution of 11.8 g (50.5 mmoles) of 4-[(methylsulfonyl)amino]benzoyl chloride in 100 ml of tetrahydrofuran. When the addition is complete, allow the mixture to warm to room temperature and stir overnight. Filter the resulting solid and wash the solid with tetrahydrofuran then with diethyl ether. Triturate the solid in acetone, then recrystallize from 90% aqueous methanol to obtain the title compound.

後処理

  1. additionWhen the addition
  2. filtrationFilter the resulting solid
  3. washwash the solid with tetrahydrofuran
  4. customTriturate the solid in acetone
  5. customrecrystallize from 90% aqueous methanol

出典と根拠

ORDレコード
ord-bd959c7efd184d809221610b3a8bd83d
出典データセット
uspto-grants-1986_12
特許番号
US04629739

反応ノート

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