Methyl 2-(4-(2-oxopropyl)phenoxy)acetate → HCID 20225248, compound

Participants

Reaction Steps

1-(4-Carbomethoxymethoxyphenyl)propan-2-one (2.20 g) and 2-methoxy-2-(2,3-difluorophenyl)ethanamine (1.87 g) in methanol (50 ml) was hydrogenated in the presence of platinum (from platinum oxide, 50 mg) until hydrogen uptake ceased. The solution was filtered through diatomaceous earth, and the solvent removed under reduced pressure. Chromatography of the residue on silica-gel eluting with 2% methanol in dichloromethane gave the title compound as an oil. The product was used in Example 54 without further purification.

Provenance & Evidence