Methyl 2-(4-(2-oxopropyl)phenoxy)acetate → HCID 20225248, compound

HRID 1249207Notes

Reaction equation

HRID 1249207 reaction equation
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14](=O)[CH3:15])=[CH:9][CH:8]=1)([O:3][CH3:4])=[O:2].[CH3:17][O:18][CH:19]([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:23]=1[F:29])[CH2:20][NH2:21].[H][H]>CO.[Pt]>[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([NH:21][CH2:20][CH:19]([O:18][CH3:17])[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:23]=2[F:29])[CH3:15])=[CH:9][CH:8]=1)([O:3][CH3:4])=[O:2]

Participants

6

Reactant 3

HCID 13851156Methyl 2-(4-(2-oxopropyl)phenoxy)acetateHCID 20225225HCID 20225225, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20225248HCID 20225248, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

1-(4-Carbomethoxymethoxyphenyl)propan-2-one (2.20 g) and 2-methoxy-2-(2,3-difluorophenyl)ethanamine (1.87 g) in methanol (50 ml) was hydrogenated in the presence of platinum (from platinum oxide, 50 mg) until hydrogen uptake ceased. The solution was filtered through diatomaceous earth, and the solvent removed under reduced pressure. Chromatography of the residue on silica-gel eluting with 2% methanol in dichloromethane gave the title compound as an oil. The product was used in Example 54 without further purification.

Workup

  1. filtrationThe solution was filtered through diatomaceous earth
  2. customthe solvent removed under reduced pressure
  3. washChromatography of the residue on silica-gel eluting with 2% methanol in dichloromethane

Sources & evidence

ORD record
ord-5dfcdffa4449458e966127e3639ade36
Source dataset
uspto-grants-1986_12
Patent number
US04629737

Reaction notes

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