HCID 53643664, compound → HCID 54472017, compound

HRID 1249219Notes

Reaction equation

HRID 1249219 reaction equation
C([O:8][C:9](=[O:58])[C@H:10]([CH2:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)[NH:11][C:12](=[O:50])[CH2:13][CH:14]([O:30][C:31](=[O:49])[CH2:32][NH:33][C:34](=[O:48])[CH2:35][NH:36][C:37](=[O:47])[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])C1C=CC=CC=1>O1CCCC1.CO>[C:37]([NH:36][CH2:35][C:34]([NH:33][CH2:32][C:31]([O:30][CH:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:13][C:12]([NH:11][C@H:10]([C:9]([OH:58])=[O:8])[CH2:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)=[O:50])=[O:49])=[O:48])(=[O:47])[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46]

Participants

4

Reactant 1

HCID 53643664HCID 53643664, compound

Product 1

HCID 54472017HCID 54472017, compoundYield 101.3%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

300 mg of the formed ester compound as above was dissolved in a mixture of 20 ml of tetrahydrofuran and 10 ml of methanol. By following the same procedure as in Example 23-(iv), 270 mg of N-[3-(N-decanoylglycylglycyloxy)octadecanoyl]-L-phenylalanine was obtained.

Sources & evidence

ORD record
ord-836d3d3532524b44a96f32719cb86bec
Source dataset
uspto-grants-1986_12
Patent number
US04629736

Reaction notes

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