Methane → HCID 13192325, compound

HRID 1249228Notes

Reaction equation

HRID 1249228 reaction equation
C.Cl.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[NH:11][C:12]([C:14]1[S:18][C:17]2=[N:19][CH2:20][CH2:21][N:16]2[C:15]=1[CH3:22])=[O:13]>O>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[NH:11][C:12]([C:14]1[S:18][C:17]2=[N:19][CH2:20][CH2:21][N:16]2[C:15]=1[CH3:22])=[O:13]

Participants

4

Reactant 2

HCID 297MethaneHCID 13192326HCID 13192326, compound2×

Product 1

HCID 13192325HCID 13192325, compoundYield 95.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A small amount of active charcoal was added to 2-(2,5-dichlorophenyl-carbamoyl)-3-methyl-5,6-dihydro-imidazo [2,1-b] thiazole hydrochloride (compound 8) (9.1 g, 0.025M) dissolved in water (300 ml), and the mixture was stirred for 10 minutes and filtered. Pyridine was added to the filtrate with stirring to adjust the pH to alkaline. The precipitated crystals were collected by filtration, completely washed with water and dried to obtain compound 7 as white powdery crystals. (8.7 g, yield: 95.6%)

Workup

  1. filtrationfiltered
  2. additionPyridine was added to the filtrate
  3. stirringwith stirring
  4. filtrationThe precipitated crystals were collected by filtration
  5. washcompletely washed with water
  6. customdried

Sources & evidence

ORD record
ord-2017f6c81c2545fa9d1a7821c827dc56
Source dataset
uspto-grants-1986_12
Patent number
US04629793

Reaction notes

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