HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-dihydro-2H-pyran → HCID 21284017, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | Ethyl 2-(4-bromo-3-hydroxybutanamido)acetate | HCID 21284022 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 21284017 | HCID 21284017 | 91% |
Reaction Steps
To a solution of 1 g ethyl 2-(4-bromo-3-hydroxybutanamido)acetate in 30 ml methylene chloride are added 100 mg pyridinium p-toluenesulphonate and 1 ml dihydropyran. Stirring is continued for 3 h at ambient temperature, the solvent is evaporated in vacuo and the residue chromatographed on silica, eluting with ether. A pale straw-coloured oil is obtained in 91% yield, Rf 0.5 (silica gel plates, thickness 0.25 mm eluent ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04629797 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-543c15138b7c4ccabaae404ceabc20ea |
| Source note | uspto-grants-1986_12 |