反应详情

To a solution of 1 g ethyl 2-(4-bromo-3-hydroxybutanamido)acetate in 30 ml methylene chloride are added 100 mg pyridinium p-toluenesulphonate and 1 ml dihydropyran. Stirring is continued for 3 h at ambient temperature, the solvent is evaporated in vacuo and the residue chromatographed on silica, eluting with ether. A pale straw-coloured oil is obtained in 91% yield, Rf 0.5 (silica gel plates, thickness 0.25 mm eluent ethyl acetate).

1. customthe solvent is evaporated in vacuo
2. customthe residue chromatographed on silica
3. washeluting with ether
4. customA pale straw-coloured oil is obtained in 91% yield, Rf 0.5 (silica gel plates