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HRID1249287

反应详情

EQUATION

反应方程式

HRID 1249287 的结构方程式

REACTANTS

反应物

2
结构：O
HCID962

Water

H2O

结构：CCCCCCCCCC(=O)N[C@H]1[C@H](Oc2c3cc4cc2Oc2ccc(cc2Cl)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@@H]2NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H]4NC(=O)[C@@H](Cc5ccc(c(Cl)c5)O3)NC(=O)[C@H](N)c3ccc(O)c(c3)Oc3cc(O)cc4c3)c3ccc(O)c(c3)-c3c(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)cc(O)cc3[C@H](C(=O)O)NC2=O)O[C@H](CO)[C@@H](O)[C@@H]1O
HCID16131923

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)N[C@@H]1[C@H](Oc2c3cc4cc2Oc2ccc(cc2Cl)[C@@H](O[C@@H]2O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]2NC(C)=O)[C@@H]2NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H]4NC(=O)[C@@H](Cc5ccc(c(Cl)c5)O3)NC(=O)[C@H](N)c3ccc(O)c(c3)Oc3cc(O)cc4c3)c3ccc(O)c(c3)-c3c(O[C@H]4O[C@H](CO)[C@@H](O)[C@@H](O)[C@@H]4O)cc(O)cc3[C@@H](C(=O)O)NC2=O)O[C@@H](CO)[C@@H](O)[C@@H]1O
HCID73348316

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：Cl
溶剂HCID313

Hydrochloric Acid

ClH

2 次

结构：OC(C(F)(F)F)C(F)(F)F
溶剂HCID13529

2H-Perfluoro-2-propanol

C3H2F6O

CONDITIONS

反应条件

温度
70 °C

PROCEDURE

实验过程

10 g of teicoplanin complex (i.e. the antibiotic complex containing teichomycin factors A1, A2 and A3, as obtained by fermentation of strain ATCC 31121 according to U.S. Pat. No. 4,239,751; the water content determined by Karl-Fischer method is 10.5% by weight) is suspended in 100 ml of 0.5 N hydrogen chloride solution in 1,1,1,3,3,3-hexafluoro-2-propanol and the suspension is heated at 70° C. with stirring while continuously bubbling anhydrous hydrogen chloride for 20 hours. Then the reaction mixture is worked up as in Example 11 yielding 3.8 g of substantially pure deglucoteicoplanin. From 0.8 g of this sample are obtained 0.5 g of crystalline pure deglucoteicoplanin by employing the procedure described in the last part of Example 1.

WORKUP

后处理

  1. customas obtained by fermentation of strain ATCC 31121 according to U.S
  2. customFrom 0.8 g of this sample are obtained 0.5 g of crystalline pure deglucoteicoplanin