反应详情

温度

50 °C

Under N2 atmosphere, 1-(4-chloro-phenyl)-3-dimethylamino-propan-1-one hydrochloride (37.2 g) was dissolved in warm MeOH (75 mL), and slowly added to a solution of hydrazine hydrate (23 mL) and 50% aqueous NaOH (12 mL) in MeOH (30 mL) stirred at 50° C. The mixture was refluxed for 2 hours, and evaporated under reduced pressure. Water was added to the residue, followed by extraction with DCM. The organic phase was washed twice with water, dried and evaporated under reduced pressure, to give 25.0 g of a yellow solid, m.p. 90-100° C.

1. temperatureThe mixture was refluxed for 2 hours
2. customevaporated under reduced pressure
3. additionWater was added to the residue
4. extractionfollowed by extraction with DCM
5. washThe organic phase was washed twice with water
6. customdried
7. customevaporated under reduced pressure