1-(2-Methoxyphenyl)piperazine → HCID 13603437, compound

HRID 1249373Notes

Reaction equation

HRID 1249373 reaction equation
[O:1]1[CH2:15][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>C(O)C>[CH2:11]([C:8]1[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH:2]([OH:1])[CH2:15][N:27]2[CH2:26][CH2:25][N:24]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[O:17][CH3:16])[CH2:29][CH2:28]2)=[CH:6][CH:7]=1)[C:12](=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 13603435HCID 13603435, compound

Product 1

HCID 13603437HCID 13603437, compoundYield 61.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

30.0 g of 4-(2,3-epoxypropoxy)-phenylacetone and 25.6 g of 2-methoxyphenyl-piperazine are heated under reflux in 300 ml of ethanol for 3 hours. The solvent is then distilled off. The residue is made to crystallise with ethyl acetate/hexane. 32.5 g of 1-[4-(propan-2-on-yl)-phenoxy]-3-[4-(2-methoxyphenyl)-piperazin-1-yl]-propan-2-ol are obtained.

Workup

  1. distillationThe solvent is then distilled off
  2. customto crystallise with ethyl acetate/hexane

Sources & evidence

ORD record
ord-36bef0fc4f964df5972aedad41b67e5e
Source dataset
uspto-grants-1986_12
Patent number
US04631281

Reaction notes

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