Phosphoric Acid → 5-Fluorouracil

HRID 1249432Notes

Reaction equation

HRID 1249432 reaction equation
[NH:1]1[CH:8]=[CH:7][C:5](=[O:6])[NH:4][C:2]1=[O:3].P(=O)(O)(O)O.[F:14]F>>[F:14][C:7]1[C:5](=[O:6])[NH:4][C:2](=[O:3])[NH:1][CH:8]=1

Participants

4

Reactant 3

HCID 1004Phosphoric AcidHCID 1174UracilHCID 24524Fluorine

Product 1

HCID 33855-Fluorouracil

Procedure

The process comprises reacting uracil in an aqueous phosphoric acid solution with elemental fluorine and heating the resultant reaction solution to form 5-fluorouracil.

Workup

  1. temperatureheating the resultant
  2. customreaction solution

Sources & evidence

ORD record
ord-38c62a9e8a5c4cecb8a5214b0adcc61c
Source dataset
uspto-grants-1986_12
Patent number
US04631342

Reaction notes

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