3-Butyn-1-OL → 4-(Pyrimidin-5-yl)butan-1-ol

HRID 1249563Notes

Reaction equation

HRID 1249563 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[N:6][CH:7]=1.[CH2:8]([OH:12])[CH2:9][C:10]#[CH:11]>>[N:4]1[CH:3]=[C:2]([CH2:11][CH2:10][CH2:9][CH2:8][OH:12])[CH:7]=[N:6][CH:5]=1

Participants

3

Reactant 2

HCID 135663-Butyn-1-OLHCID 783445-Bromopyrimidine

Product 1

HCID 135575424-(Pyrimidin-5-yl)butan-1-ol

Procedure

5-bromopyrimidine and 3-butyn-1-ol was reacted as above, to give 5-pyrimidinebutanol as a colorless oil, bp 175°-180° C. (0.3 mm). Analysis Calculated for C8H12N2O: C, 63.13; H, 7.95; N, 18.41. Found: C, 62.83; H, 7.98; N, 18.63.

Sources & evidence

ORD record
ord-7595279c57dc4e6eb08820b866f4c1df
Source dataset
uspto-grants-1986_12
Patent number
US04632925

Reaction notes

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