反应详情

A solution of alpha,alpha-bis(3-methoxyphenyl)-4-piperidine-ethanol (15 g) in trifluoroacetic acid (30 ml) was stirred at ambient temperature for one hour, then the solvent was removed in vacuo. The residue was partitioned between toluene (50 ml) and 1N sodium hydroxide (100 ml), and the separated aqueous layer was reextracted with toluene (20 ml). The combined toluene extracts were washed with 1N sodium hydroxide solution, then were dried over potassium carbonate and evaporated to give 12.8 g of 4-[2,2-bis(3-methoxyphenyl)ethenyl]piperidine as an oil.

1. customthe solvent was removed in vacuo
2. customThe residue was partitioned between toluene (50 ml) and 1N sodium hydroxide (100 ml)
3. washThe combined toluene extracts were washed with 1N sodium hydroxide solution
4. dry with materialwere dried over potassium carbonate
5. customevaporated