Methylamine → HCID 13536119, compound

HRID 1249610Notes

Reaction equation

HRID 1249610 reaction equation
[Cl:1][C:2]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:14]([O-:16])=[O:15])=[C:9]([C:11](=O)[CH3:12])[CH:10]=1.[CH3:25][NH2:26]>C(O)C>[CH3:25][N:26]=[C:11]([C:9]1[CH:10]=[C:5]([O:4][C:3]2[CH:17]=[CH:18][C:19]([C:21]([F:24])([F:23])[F:22])=[CH:20][C:2]=2[Cl:1])[CH:6]=[CH:7][C:8]=1[N+:14]([O-:16])=[O:15])[CH3:12]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 13017564HCID 13017564, compound

Product 1

HCID 13536119HCID 13536119, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenyl ethanone (3.3 g., 0.0092 mole) in absolute ethanol (30 ml) was bubbled methylamine for 0.5 hour as the temperature rose to about 40° C. The solution was stirred for 12 hours at room temperature and then heated to reflux for 4 hours. The solvent was stripped to give 3.0 g of a brown oil. Recrystallization from methanol/water gave a brown solid (1.2 g., mp. 133°-7° C.).

Workup

  1. customrose to about 40° C
  2. temperatureheated
  3. temperatureto reflux for 4 hours

Sources & evidence

ORD record
ord-be9143ab1f2945a8b8b2e9a18689d6c7
Source dataset
uspto-grants-1986_12
Patent number
US04633000

Reaction notes

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