Sodium Hydroxide → 5-Hydroxyisophthalic acid

HRID 1249643ノート

反応式

HRID 1249643 の反応式
S([C:5]1[CH:6]=[C:7]([C:14]([O-:16])=[O:15])[CH:8]=[C:9]([CH:13]=1)[C:10]([O-:12])=[O:11])(O)(=O)=O.[Na+].[Na+].[Na+].[OH-:20].[Na+].C1(C(C2C=CC=C(C)C=2C)C)C=CC=CC=1>O>[OH:20][C:5]1[CH:6]=[C:7]([C:14]([OH:16])=[O:15])[CH:8]=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 3033855Dimethyl(1-phenylethyl)benzeneHCID 20223815HCID 20223815、化合物

生成物 1

HCID 692575-Hydroxyisophthalic acid収率 94.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
280 °C

実験手順

Trisodium 5-sulfoisophthalate (312 g) was added to 170 g of a 50% aqueous solution of sodium hydroxide, and the mixture was stirred. Then, 1980 g of 1-phenyl-1-(2,3-dimethylphenyl)-ethane was mixed, and the resulting mixture was heated to 280° C. in a nitrogen stream and dehydrated with stirring. The dehydrated mixture was stirred at 280° C. for 1.5 hours. After cooling, 1 liter of water was added to the reaction mixture to separate the reaction medium. The aqueous layer was decolorized with activated carbon, and precipitated with dilute sulfuric acid to give 172.5 g (yield 94.8%) of 5-hydroxyisophthalic acid.

後処理

  1. stirringwith stirring
  2. stirringThe dehydrated mixture was stirred at 280° C. for 1.5 hours
  3. temperatureAfter cooling
  4. customto separate the reaction medium
  5. customprecipitated with dilute sulfuric acid

出典と根拠

ORDレコード
ord-518834d0c8e6470688cdd7a9923409dc
出典データセット
uspto-grants-1986_12
特許番号
US04633024

反応ノート

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