反应详情

温度

60 °C

To a suspension of 10 g of 5-[3-(4-methoxyphenyl)propionyl]barbituric acid in 100 ml of acetic acid are added portionwise 4.5 g of sodium cyanoborohydride, then the mixture is heated to 60° C. After 1 hour the reaction mixture is cooled to room temperature and poured into ice. After 30 minutes a solid is recovered by filtration, which is dried under vacuum at 50° C. to give 8.74 g of the product, m.p. 195-197° C.

1. temperatureAfter 1 hour the reaction mixture is cooled to room temperature
2. additionpoured into ice
3. filtrationAfter 30 minutes a solid is recovered by filtration, which
4. customis dried under vacuum at 50° C.