反应详情

A suspension of (4′-biphenyl)acetic acid (6.4 g) in 60 ml of ethanol is added with 1.1 g of para-toluensulfonic acid, then the reaction mixture is refluxed for 4 hours 30 minutes. The solvent is evaporated off, the residue is dissolved in diethyl ether and the resulting organic phase is washed three times with a saturated aqueous solution of sodium hydrogencarbonate and once with brine. The organic phase is then dried over sodium sulfate and the solvent is evaporated off to give 7.1 g of the product as a yellow oil.

1. temperaturethe reaction mixture is refluxed for 4 hours 30 minutes
2. customThe solvent is evaporated off
3. dissolutionthe residue is dissolved in diethyl ether
4. washthe resulting organic phase is washed three times with a saturated aqueous solution of sodium hydrogencarbonate
5. dry with materialThe organic phase is then dried over sodium sulfate
6. customthe solvent is evaporated off