Hydrochloric Acid → HCID 18328910, compound

Participants

Reaction Steps

Ethyl acetate saturated with gaseous HCl (50 ml) was added to a solution of 1-tert-butoxycarbonyl-4-[1-(2-methylpyrimidin-4-yl)piperazin-4-ylmethyl]piperidine (3.02 g) in ethyl acetate (15 ml) and the resulting suspension stirred at ambient temperature for 3 hours. Solvent was evaporated to give 4-[1-(2-methylpyrimidin-4-yl)piperazin-4-ylmethyl]piperidine trihydrochloride (2.78 g) as a colourless foam.

Provenance & Evidence