Hydrochloric Acid → HCID 18328910, compound

HRID 1249721Notes

Reaction equation

HRID 1249721 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[CH:26][N:25]=[C:24]([CH3:28])[N:23]=3)[CH2:18][CH2:17]2)[CH2:11][CH2:10]1)=O)(C)(C)C>C(OCC)(=O)C>[ClH:1].[ClH:1].[ClH:1].[CH3:28][C:24]1[N:23]=[C:22]([N:19]2[CH2:20][CH2:21][N:16]([CH2:15][CH:12]3[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]3)[CH2:17][CH2:18]2)[CH:27]=[CH:26][N:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18328903HCID 18328903, compound

Product 1

HCID 18328910HCID 18328910, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

Ethyl acetate saturated with gaseous HCl (50 ml) was added to a solution of 1-tert-butoxycarbonyl-4-[1-(2-methylpyrimidin-4-yl)piperazin-4-ylmethyl]piperidine (3.02 g) in ethyl acetate (15 ml) and the resulting suspension stirred at ambient temperature for 3 hours. Solvent was evaporated to give 4-[1-(2-methylpyrimidin-4-yl)piperazin-4-ylmethyl]piperidine trihydrochloride (2.78 g) as a colourless foam.

Workup

  1. customSolvent was evaporated

Sources & evidence

ORD record
ord-07ba4f0a39fd4c3d9c614b1d088a9d74
Source dataset
uspto-grants-2002_01
Patent number
US06335341B1

Reaction notes

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