HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[4-(4-Pyridyl)-1-piperidylmethyl]piperidine trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Tert-butoxycarbonyl-4-[4-(4-pyridyl)-1-piperidylmethyl]piperidine | HCID 18328914 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-[4-(4-Pyridyl)-1-piperidylmethyl]piperidine trihydrochloride | HCID 18328927 | — |
Reaction Steps
Ethyl acetate saturated with gaseous HCl (50 ml) was added to a solution of 1-tert-butoxycarbonyl-4-[4-(4-pyridyl)-1-piperidylmethyl]piperidine (1.65 g) in ethyl acetate (25 ml) and the resulting suspension stirred at ambient temperature for 3 hours. Solvent was evaporated to give 4-[4-(4-pyridyl)-1-piperidylmethyl]piperidine trihydrochloride (1.60 g) as a colourless foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06335341B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-e07d73e7dda7461fbe88d4d4b979e82c |
| Source note | uspto-grants-2002_01 |