Hydrochloric Acid → 4-[4-(4-Pyridyl)-1-piperidylmethyl]piperidine trihydrochloride

HRID 1249724Notes

Reaction equation

HRID 1249724 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([C:22]3[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=3)[CH2:18][CH2:17]2)[CH2:11][CH2:10]1)=O)(C)(C)C>C(OCC)(=O)C>[ClH:1].[ClH:1].[ClH:1].[N:25]1[CH:24]=[CH:23][C:22]([CH:19]2[CH2:18][CH2:17][N:16]([CH2:15][CH:12]3[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]3)[CH2:21][CH2:20]2)=[CH:27][CH:26]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18328914HCID 18328914, compound

Product 1

HCID 183289274-[4-(4-Pyridyl)-1-piperidylmethyl]piperidine trihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

Ethyl acetate saturated with gaseous HCl (50 ml) was added to a solution of 1-tert-butoxycarbonyl-4-[4-(4-pyridyl)-1-piperidylmethyl]piperidine (1.65 g) in ethyl acetate (25 ml) and the resulting suspension stirred at ambient temperature for 3 hours. Solvent was evaporated to give 4-[4-(4-pyridyl)-1-piperidylmethyl]piperidine trihydrochloride (1.60 g) as a colourless foam.

Workup

  1. customSolvent was evaporated

Sources & evidence

ORD record
ord-e07d73e7dda7461fbe88d4d4b979e82c
Source dataset
uspto-grants-2002_01
Patent number
US06335341B1

Reaction notes

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