反应详情

A mixture of 7H-[1,3]dioxolo[4,5-g]quinazolin-8-one (0.550 g, 2.78 mmol) and phosphorus pentachloride (0.800 g, 3.84 mmol) in 3 mL phosphorus oxychloride was heated to a gentle reflux for 2.5 hours. Solvent was removed in vacuo, and azeotroped with toluene. Residue was dissolved in ethyl acetate and washed with 5% sodium bicarbonate solution and then filtered, and then solvent was removed in vacuo to give 8-chloro-[1,3]dioxolo[4,5-g]quinazoline (0.400 g, 74%).

1. temperaturewas heated to
2. temperaturea gentle reflux for 2.5 hours
3. customSolvent was removed in vacuo
4. customazeotroped with toluene
5. dissolutionResidue was dissolved in ethyl acetate
6. washwashed with 5% sodium bicarbonate solution
7. filtrationfiltered
8. customsolvent was removed in vacuo