HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Piperazinylpyrimidine dihydrochloride → 1-(2-Pyrimidinyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Piperazinylpyrimidine dihydrochloride | HCID 11680272 | — |
| Solvent | Sodium Chloride | HCID 5234 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 1-(2-Pyrimidinyl)piperazine | HCID 88747 | 93.7% |
Reaction Steps
A solution of 1-(2-pyrimidyl)piperazine dihydrochloride (4.0 g, 16.9 mmol) in 1N sodium hydroxide saturated with sodium chloride (40 ml) was extracted with ethyl acetate (2×30 ml). The organic layer was dried over sodium sulfate, filtered and concentrated to give 2.6 g of 1-(2-pyrimidyl)piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06335324B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-c1f8c02a41ee414e8581eaf80f8725a9 |
| Source note | uspto-grants-2002_01 |