2-Piperazinylpyrimidine dihydrochloride → 1-(2-Pyrimidinyl)piperazine

HRID 1249756Notes

Reaction equation

HRID 1249756 reaction equation
Cl.Cl.[N:3]1[CH:8]=[CH:7][CH:6]=[N:5][C:4]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>[OH-].[Na+].[Cl-].[Na+].C(OCC)(=O)C>[N:3]1[CH:8]=[CH:7][CH:6]=[N:5][C:4]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1

Participants

5

Reactant 1

HCID 116802722-Piperazinylpyrimidine dihydrochloride

Product 1

HCID 887471-(2-Pyrimidinyl)piperazineYield 93.7%

Reagents, catalysts & solvents 3

HCID 5234Sodium ChlorideSolventHCID 8857Ethyl AcetateSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of 1-(2-pyrimidyl)piperazine dihydrochloride (4.0 g, 16.9 mmol) in 1N sodium hydroxide saturated with sodium chloride (40 ml) was extracted with ethyl acetate (2×30 ml). The organic layer was dried over sodium sulfate, filtered and concentrated to give 2.6 g of 1-(2-pyrimidyl)piperazine.

Workup

  1. dry with materialThe organic layer was dried over sodium sulfate
  2. filtrationfiltered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-c1f8c02a41ee414e8581eaf80f8725a9
Source dataset
uspto-grants-2002_01
Patent number
US06335324B1

Reaction notes

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