HCID 69375727, compound → HCID 69376670, compound

HRID 1249776Notes

Reaction equation

HRID 1249776 reaction equation
C([NH:4][C:5]1[N:10]=[C:9]2[NH:11][CH:12]=[C:13]([CH:14]=[C:15]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:16]([NH2:18])=[O:17])[C:8]2=[CH:7][CH:6]=1)(=O)C.O.[Na]>CO>[NH2:4][C:5]1[N:10]=[C:9]2[NH:11][CH:12]=[C:13]([CH:14]=[C:15]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:16]([NH2:18])=[O:17])[C:8]2=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 69375727HCID 69375727, compoundHCID 71353970Sodium monohydrate

Product 1

HCID 69376670HCID 69376670, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 g (3.13 mmol) of 3-(6-acetylamino-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-phenyl-2-propenamide was dissolved in 20 ml of methanol and 3.13 ml of sodium hydrate 1 M were added. The solution is maintained at room temperature for 5 hours and then concentrated under vacuum. The residue was redissolved with dichloromethane and washed with water. The organic layer was finally dried over sodium sulfate and evaporated to give 696 mg (80% yield) of the title compound.

Workup

  1. concentrationconcentrated under vacuum
  2. dissolutionThe residue was redissolved with dichloromethane
  3. washwashed with water
  4. dry with materialThe organic layer was finally dried over sodium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-e49ec2abca5040449bd9c6ec615103f9
Source dataset
uspto-grants-2002_01
Patent number
US06335342B1

Reaction notes

Loading…